- Addi and Cassi’s FDA Cyclodextrin Submission
- Meet Addi and Cassi
- What is Niemann Pick Type C disease?
- Cyclodextrin and Drug Delivery
- Cyclodextrin and Odor Prevention
- Cyclodextrin on Wikipedia
- Cyclodextrin Overview - List of Uses and Drugs
- Cyclodextrin Scientific Papers
- Procter & Gamble Cyclodextrin Overview
- Society Of Cyclodextrins
- Sporanox: Approved Drug Containing Cyclodextrin
- CoQ10 and Cyclodextrin
- Cyclodextrin Releases Trapped Cholesterol
- KTVU Story On The Power of Cyclodextrin
- Take Drug Additive, Not Drug?
- Washington DC HIV/AIDs Epidemic
- Dr. James E. K. Hildreth, HIV/AIDS
- Dr. John Dietschy, Niemann Pick Type C
- Dr. Lajos Szente
- Dr. Len Kritharides, Vascular & Cholesterol Research
- Dr. Steven Walkley, Niemann Pick Type C
Wacker Chemie Expands US Based Cyclodextrin Facility To Meet Increase In Worldwide Demand For Sugar Molecule
June 12th, 2009

Wacker Chemie, the Munich-based chemical company, announced that is has expanded its US based cyclodextrin facility in Eddyville, Iowa. According the the press release issued by Wacker, the new cyclodextrin facility increases the company’s capacity for alpha (α) and beta (β) cyclodextrins by 50 percent and doubles its capacity for gamma (γ) cyclodextrins.
Investment in the entire facility totaled over $21 million and will enable Wacker to produce up to 7,500 metric tons of cyclodextrins a year. The extra capacity is needed to meet the worldwide rise in cyclodextrin demand.
According to the press release, “the ability to reversibly enclose other substances makes cyclodextrins invaluable in many products such as pharmaceuticals, cosmetics, textiles and food, not to mention in the household-care, personal-care and construction sectors.”
What about entrapping cholesterol in the human body and helping get rid of it? Interestingly, Wacker’s press release does not mention hydroxy propel beta cyclodextrin (HPBCD) and its potential health benefits.
This is the type of cyclodextrin we are giving via intravenous infusions to Addi and Cassi for their fatal cholesterol metabolism disease, Niemann Pick Type C (otherwise known as the “childhood Alzhiemer’s.”) Hydroxy propel beta cyclodextrin is somehow grabbing the stuck cholesterol and taking it out of the twins’ bodies through urine/stool. I wonder if Wacker even knows of this cyclodextrin project or the fact that HPBCD also kills the HIV AIDS virus.
Here are some great facts on cyclodextrins from Wacker:
- Cyclodextrins are cyclic sugar molecules. The number of glucose units defines the size of the sugar ring – alpha-cyclodextrin has six, beta-cyclodextrin seven, and gamma-cyclodextrin eight glucose units
- Cyclodextrins are able to enclose other substances in their interiors, much like a cone encloses a scoop of ice-cream. This enables cyclodextrins to bind ingredients, release active agents and stabilize sensitive substances such as vitamins and coenzyme
- Cyclodextrins have the ability to reversibly enclose other substances making cyclodextrins invaluable in many products such as pharmaceuticals, cosmetics, textiles and food, household and personal-care
The best part of the whole announcement was this statement — cyclodextrins of all types are non-toxic, non-allergenic and pose no known health risks based on today’s scientific findings!
Filed under Cyclodextrin Research, News | Comment (0)Cyclodextrin. HIV AIDS. Niemann Pick Type C. Cholesterol. Sugar Killing HIV? Who Would Have Imagined This?
April 1st, 2009
Millions of children in Africa like Rosine are needlessly contracting HIV/AIDS when an inexpensive and non toxic sugar compound called Cyclodextrin (or HPBCD) kills the HIV/AIDS virus and could literally stop the spread of this horrible deadly disease from mother to child (not to mention adults!). Now that the world is going to find out how important the Niemann Pick Type C GENE and proteins (located on Chromosome 18) are to the HIV/AIDS viruses ability to create itself and replicate in an infected person’s body, there may be some significant breakthroughs on the horizon.

Rachel and Rosine - Africa Children With HIV/AIDS
Rosine’s HIV/AIDS infection is being spread through her body with the helps of the Niemann Pick Type C proteins which help the HIV/AIDS virus makes itself inside a person’s cells. Cyclodextrin sugar is having miraculous effect on the HIV/AIDS virus (it’s killing the virus in animals!). Millions of children in Africa contract HIV/AIDS through the birth canal. Imagine the possibilities of pregnant mothers in Africa having an inexpensive and safe cream applied inside the birth canal prior to giving birth? The virus could be stopped - today! Cyclodextrin is readily available and simply needs to be tested in humans and deployed to see if it can work as effectively on people as it does in animals.

Addi & Cassi Hempel - Twins with Niemann Pick Type C
Cyclodextrin treatment is being tried as a potential therapy in Niemann Pick Type C DISEASE, which afflicts 5 year old identical twins, Addi and Cassi Hempel. Addi and Cassi were born with two “genetic defects” or inherited “mutations” from their parents on the Niemann Pick Type C GENE. These mutations on the GENE cause a fatal cholesterol metabolism DISEASE that is often referred to as “Childhood Alzheimer’s.” The FDA recently approved a “compassionate use” IND to allow the twins to receive cyclodextrin infusions directly into their bloodstreams. With cyclodextrin having such a profound effect on cellular cholesterol in mice studies and on viruses like HIV/AIDS attach to cholesterol when they enter the body like HIV/AIDS, imagine what else it might do if more research was done on this compound?
Thanks to Kresta King Cutcher Venning for sharing her beautiful pictures of children in Africa who are suffering from HIV/AIDS. This picture of Rosine was taken in 2006 and she is still battling her HIV/AIDS infection. Together we must bring the story of children and families in different parts of the world who are fighting what seems to be entirely different fatal diseases, but are really connected through cholesterol, to the world!
Filed under Cholesterol, Cyclodextrin, News | Comment (0)




