June 12th, 2009
Wacker Chemie, the Munich-based chemical company, announced that is has expanded its US based cyclodextrin facility in Eddyville, Iowa. According the the press release issued by Wacker, the new cyclodextrin facility increases the company’s capacity for alpha (α) and beta (β) cyclodextrins by 50 percent and doubles its capacity for gamma (γ) cyclodextrins.
Investment in the entire facility totaled over $21 million and will enable Wacker to produce up to 7,500 metric tons of cyclodextrins a year. The extra capacity is needed to meet the worldwide rise in cyclodextrin demand.
According to the press release, “the ability to reversibly enclose other substances makes cyclodextrins invaluable in many products such as pharmaceuticals, cosmetics, textiles and food, not to mention in the household-care, personal-care and construction sectors.”
What about entrapping cholesterol in the human body and helping get rid of it? Interestingly, Wacker’s press release does not mention hydroxy propel beta cyclodextrin (HPBCD) and its potential health benefits.
This is the type of cyclodextrin we are giving via intravenous infusions to Addi and Cassi for their fatal cholesterol metabolism disease, Niemann Pick Type C (otherwise known as the “childhood Alzhiemer’s.”) Hydroxy propel beta cyclodextrin is somehow grabbing the stuck cholesterol and taking it out of the twins’ bodies through urine/stool. I wonder if Wacker even knows of this cyclodextrin project or the fact that HPBCD also kills the HIV AIDS virus.
Here are some great facts on cyclodextrins from Wacker:
- Cyclodextrins are cyclic sugar molecules. The number of glucose units defines the size of the sugar ring – alpha-cyclodextrin has six, beta-cyclodextrin seven, and gamma-cyclodextrin eight glucose units
- Cyclodextrins are able to enclose other substances in their interiors, much like a cone encloses a scoop of ice-cream. This enables cyclodextrins to bind ingredients, release active agents and stabilize sensitive substances such as vitamins and coenzyme
- Cyclodextrins have the ability to reversibly enclose other substances making cyclodextrins invaluable in many products such as pharmaceuticals, cosmetics, textiles and food, household and personal-care
The best part of the whole announcement was this statement — cyclodextrins of all types are non-toxic, non-allergenic and pose no known health risks based on today’s scientific findings!
Filed under Cyclodextrin Research, News | Comment (0)
March 22nd, 2009
With the FDA approval now in hand and mediports installed, we are working towards starting intravenous infusions of Hydroxy Propel Beta Cyclodextrin on Addi and Cassi. We are currently capturing a full set of baseline testing on the twins (blood, urine and stool samples) for our doctors and researchers to study. Intravenous cyclodextrin treatments have never been attempted before to remove cholesterol from the cells and organs of living people, we have had to set up an entirely new testing and safety protocol from scratch. This has taken months of work.
Since Cyclodextrin is not a drug, is non-toxic and is already going into the human body through a drug called Sporanox, we were able to make the argument with the FDA to allow us to treat Addi and Cassi under “compassionate use.” Essentially, we have created our own personal clinical trial with our identical twins in order to try this sugar compound to see if it can extend or save their lives.
Addi and Cassi recently underwent neuropsychological exams by Dr. Seth Ubody at Children’s Hospital Oakland to capture neurological baselines. We will also be doing spleen and liver measurements and a whole host of other tests prior to starting the cyclodextrin infusions. Once we have all the baselines in place, the infusions will begin. Baseline samples can then be compared to samples collected following cyclodextrin treatment to see if there are any measurable changes.
The current plan is to admit Addi and Cassi to Renown Regional Medical Center where the girls will undergo 24 hour continuous infusions of cyclodextrin for 4 straight days (Note: If anyone reading this blog has extra children’s videos they don’t need, please send them to us!) After receiving 4 days of continuous infusions of cyclodextrin, the girls will become out patients and receive infusions 1x per week for 8 hours. We plan to carve out Friday’s for these infusions and we’ll be spending a lot of time at the hospital. Our goal is to eventually administer cyclodextrin infusions at home with the help of a home health nurse.
Right now, we have no idea what dose of cyclodextrin might have a therapeutic effect or if it will move cholesterol out of Addi and Cassi cells and bodies like it does in Niemann Pick Type C mice. We must start at a low level for safety purposes and then begin to scale up cyclodextrin doses. After 3 months, we plan to go back to the FDA and ask them to allow us to give Addi and Cassi slightly different doses of cyclodextrin so we can accelerate finding the ideal therapeutic dose. Since the girls are identical twins, they can work together to find the perfect dose.
To read more about Cyclodextrin, please visit Addi and Cassi’s website:
FDA Approves Addi and Cassi’s Cyclodextrin Infusions For Twins Who Suffer From Niemann Pick Type C:
http://addiandcassi.com/np-c/fda-approves-first-ever-cyclodextrin-infusion-treatment-for-twin-girls-suffering-from-fatal-cholesterol-disease-called-niemann-pick-type-c/
Johnson and Johnson Provides Cyclodextrin Safety Data to the FDA To Help Twins, Addi and Cassi Hempel:
http://addiandcassi.com/np-c/thank-you-johnson-johnson-for-helping-sick-kids/
http://addiandcassi.com/np-c/fda-reviewing-application-to-give-cyclodextrin-sugar-compound-to-5-year-old-twins-stricken-with-fatal-cholesterol-disorder/
Filed under Cholesterol, Cyclodextrin, Niemann Pick Type C | Comment (0)
March 21st, 2009
April 1st, 2009
Bay Area Television station KTVU Channel 2 reports on the remarkable story of how two deadly diseases, one extremely rare and one a global epidemic, are connected by a cholesterol metabolism gene called Niemann Pick Type C located on Chromosome 18.
Dr. James Hildreth, a pre-eminent HIV/AIDS researcher who heads the Center for AIDS Health Disparities Research at Meharry Medical College in Nashville discusses how a non toxic sugar compound called cyclodextrin kills HIV/AIDS. Cyclodextrin punches holes in the virus, inactivating its ability to replicate in the body.
When HIV enters the human body, it attaches itself to cholesterol. Dr. Hildreth has discovered how HIV creates itself in a person’s cells — by utilizing the Niemann Pick Type C proteins on Chromosome 18.
The story details how 5 year old identical twins, Addi and Cassi Hempel, who were born with a defect on the Niemann Pick Type C gene, will receive infusions of cyclodextrin into their bloodstreams to help treat their rare cholesterol disorder. Their treatment could pave the way for future HIV/AIDS therapies.
Filed under Cholesterol | Comments Off
